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This guide to provides evidence-based recommendations for interventions during pregnancy, labor and during the newborn period that are aimed at improving outcomes for preterm infants. The guide is intended to be used by health-care professionals responsible for developing national and local health-care protocols and policies, as well as managers of maternal and child health programs and public health policy-makers in all settings. The guide is also useful to health care professionals providing care to pregnant women and preterm infants.