Operationalization of WHO guidelines for managing possible serious bacterial infection (PSBI) in young infants

Infections remain a leading cause of newborn deaths globally. In 2015, WHO issued a guideline for managing possible serious bacterial infection (PSBI) in young infants (0-59 days) using simplified antibiotic regimens – including fewer injections, provided closer to the community – when compliance with hospital referral is not feasible. The guideline aims...

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Using Benchmarks to Assess Progress Towards Operationalizing PSBI Guidelines

In 2017 WHO, Save the Children, UNICEF, and USAID, in collaboration with program managers and policy makers, developed a set of 23 benchmarks to monitor national-level progress in implementation of a new guideline for possible serious bacterial infection (PSBI) in young infants when referral is not feasible. These 23 benchmarks, outlined in...

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Integrating Simplified Treatment Regimens to Manage Sepsis in Sick Young Infants

This blog was originally published on USAID's Health Research Program website here. By Samira Aboubaker Neonatal infections including pneumonia, sepsis, and meningitis are responsible for 21% of neonatal deaths annually and were responsible for over 550,000 out of 2.6 million neonatal deaths in 2016.1 Timely and appropriate inpatient care and...

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Rethinking management of neonates at risk of sepsis

Clinicians involved in the care of young infants are aware of the consequences of not administering or of delaying antibiotics in cases of bacterial sepsis. Those who have seen such cases might be quicker to prescribe antibiotics in the future, even if sepsis is a remote possibility. However, this practice...

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