In many countries, RMNCH services represent the primary point of women’s and children’s access to the health system. The stakeholders, messages and services for HIV, tuberculosis (TB) and malaria and for reproductive, maternal, newborn and child health (RMNCH) are closely interconnected. When integrated with prevention, care and treatment for other health concerns, coverage for these three priority diseases can be greatly enhanced. There are multiple entry points along the RMNCH continuum of care to integrate HIV, TB and malaria strategies, and opportunities exist to strengthen health systems and community structures. An appropriate approach will avoid duplication and maximise effectiveness, efficiency and quality. It will also promote human rights and accountability for shared indicators and results. Several initiatives currently support the integration of HIV, TB and malaria services with RMNCH services. Further expansion of these efforts could significantly improve the health of women and children.